Opioid substitution therapy in Nepal

Learning from building a national programme

Opioid Substitution Therapy in Nepal

This case study explores learnings generated during the establishment of Nepal’s national opioid substitution therapy (OST) programme, a process which has been led by the government of Nepal and Nepalese civil society organisations with support from German Development Cooperation and other international development partners.

The challenge: Injecting drug users in Nepal lack harm reduction interventions

The estimated 52,000 people in Nepal who inject drugs face a range of health problems, including an elevated risk of blood-borne infections: nationally 6.3% of people who inject drugs are HIV-positive and between 22 and 47%, depending on the region, are infected with hepatitis C. People who are dependent on drugs struggle to access comprehensive health and psychosocial care. The government plays a limited role in the provision of treatment and rehabilitation services. Privately-run programmes are of variable quality, are unaffordable for many, and generally favour abstinence-based approaches which are associated with high relapse rates. Although Nepal was the first country in Asia to allow harm reduction interventions for people who inject drugs, it has not fully embraced a public health approach to drug use.

The response: Building a national opioid substitution therapy programme

Since 2009, through a series of technical cooperation projects on harm reduction implemented on behalf of Germany’s Federal Ministry for Economic Cooperation and Development (BMZ), the Deutsche Gesellschaft für Internationale Zusammenarbeit (GIZ) has worked with national and international partners to expand the availability of OST in Nepal. Starting from an existing pilot project authorised by the Ministry of Home Affairs, and informed by Germany’s own experience with OST, advisors with the harm reduction projects have systematically built up six pillars of a sustain- able national OST programme.

In order to strengthen the policy framework and to position OST as a public health intervention, the project advocated for the Ministry of Home Affairs to share responsibility for OST with the Ministry of Health and to allow the service to be administered at public hospitals and by non-governmental organisations (NGOs). Key policy documents – e.g. management guidelines, clinical guidelines and standard operating procedures for the provision of psychosocial support services – were developed and approved. The project helped to secure stable financing for a scaled-up OST programme from the Global Fund to Fight AIDS, Tuberculosis and Malaria, which has been covering the costs of medical and psychosocial support services for OST patients in Nepal since 2011.

At the same time, the project improved the clinical provision of substitution therapy by training a cohort of OST doctors and nurses according to a standard curriculum, providing continuous on-the-job coaching, and working with the German company CompWare Medical to set up fully automated methadone dispensing machines with integrated patient documentation systems at each OST site. In the absence of qualified social workers, the project trained ex-drug users working for NGOs to provide psychosocial support services to OST patients. A training curriculum and standard operating procedures to guide the work of Social Support Units were developed through a participatory process. Training curricula for both medical and social support staff emphasise OST as one part of comprehensive care for people who inject drugs. OST patients are referred for additional services as needed, including screening for HIV, tuberculosis and hepatitis.

To strengthen systems for monitoring and evaluating OST, the project supported the establishment of patient record-keeping systems at OST sites and built the organisational capacity of two local institutions to take over the training and supervision of Medical and Social Support Units following the end of German support for harm reduction in mid-2016.

What has been achieved

  • OST has been elevated to the status of a national programme under the Ministry of Health and is implemented in cooperation with the Ministry of Home Affairs in accordance with country-specific policy documents aligned to international standards.
  • Through continuous sensitisation and advocacy for OST, harm reduction approaches for people who inject drugs have attained greater prominence in Nepal and have added weight to civil society-led efforts to reform national drug policy.
  • Innovative approaches which bring together governmental and non-governmental actors in the delivery of OST (e.g. NGO-run sites and the provision of psychosocial support by ex-drug users) have been integrated into the design of the national OST programme.
  • Using approved national training curricula developed by the project, more than 60 clinicians and 90 ex-drug users have been trained to work in the OST programme. Tribhuvan University Teaching Hospital and the NGO Recovering Nepal have assumed responsibility for training and supervising OST Medical and Social Support Units.
  • Psychosocially-assisted OST is provided on a decentralised basis at seven public hospitals and four NGO-run sites to approximately 900 patients in four regions of Nepal. Both methadone and buprenorphine are approved for use.


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